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MONTGOMERY, Ala. "The approval is the culmination of over three years of effort from our partners at Applied Pharma Research and the internal team at Kowa," said William Maichle, Chief Operating Officer of Kowa Pharmaceuticals America, Inc. is a privately held multinational company headquartered in Nagoya, Japan. Established in 1894, Kowa is actively engaged in various manufacturing and trading activities in the fields of pharmaceutical, life science, information technology, textiles, machinery and various consumer products. About Applied Pharma Research APR Applied Pharma Research SA is an independent, international, vertically integrated drug delivery and drug development company in healthcare with registered offices in Switzerland and the U. About Acura Pharmaceuticals, Inc..